2004•Chinese New Drugs JournalRequires access
Molecular mechanisms for drug resistance of Candida albicans
Jiang Yuan-ying
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Abstract
The emergence of fluconazole-resistant Candida albicans strains is a significant problem after long-term treatment. Multiple molecular mechanisms contribute to the development of resistance in Candida albicans .including mutations or overexpression of the drug target enzyme in sterol biosynthesis, such as sterol 14α-demethylase,alternations of intracellular drug concentration by multidrug resistance pumps and the formation of biofilm in Candide albicans.