成明建, 宋文霞, 黄齐慧
Abstract
目的 研究几种常用促渗剂对奥沙普秦体外经皮渗透的影响.方法用紫外分光光度法检测浓度,采用改进Franz扩散池,比较几种常用促渗剂对奥沙普秦渗透速率的影响.结果氮酮(Azone)单独使用不能明显提高奥沙普秦的渗透速率(P＞0.05),而丙二醇、薄荷醇、Azone+丙二醇(1:1)、丙二醇+薄荷醇(1:1)能显著提高奥沙普秦的渗透速率(P＜0.01).结论丙二醇、薄荷醇、Azone+丙二醇(1:1)、丙二醇+薄荷醇(1:1)可作为促渗剂用于奥沙普秦经皮吸收制剂。
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目的 研究几种常用促渗剂对奥沙普秦体外经皮渗透的影响.方法用紫外分光光度法检测浓度,采用改进Franz扩散池,比较几种常用促渗剂对奥沙普秦渗透速率的影响.结果氮酮(Azone)单独使用不能明显提高奥沙普秦的渗透速率(P＞0.05),而丙二醇、薄荷醇、Azone+丙二醇(1:1)、丙二醇+薄荷醇(1:1)能显著提高奥沙普秦的渗透速率(P＜0.01).结论丙二醇、薄荷醇、Azone+丙二醇(1:1)、丙二醇+薄荷醇(1:1)可作为促渗剂用于奥沙普秦经皮吸收制剂。
Key concepts: Penetration (warfare), Permeation, Chemistry, In vitro, Mathematics, Biochemistry, Membrane, Operations research