Drug-releasing and transdermal test of Jingliukang Cataplasmata in vitro

AIM:To explore optimal concentration of the penetration enhancerslaurocapam(azone) for Jingliukang Cataplasmata(Rhizoma Chuanxiong,Herba Menthae,Rhizoma Bolbostematis,Pseudobulbus Cremastrae seu pleiones,Borneolum Syntheticum,etc.) METHODS: The in vitro release cumulative percentage of drug tubeimoside from cataplasmata was selected as marker with extracorporeal rabbit skin in a improved Franz diffusion cell to calculate transdermal rate and transdermal amounts of dosage of azone-free,1%,2% and 3% azone addition. RESULTS: Transdermal result of azoue-free,1% and 2% azone addition met with logavithmic normal distribution,of 3% azone addition met with Weibull distribution.1% azone without substrate was zero dymanic model.transderma amount of tubeimoside in adding 1% or 3% azone was 4.5-4.9 time than that without azone,1.4-1.5 time than that adding 2% azone transdermal rate in adding 1% or 3% azone was 4.2-5.6 times than that adding 2% azone more than that without azone. CONCLUSION: Adding 1% azone into Jingliukang Cataplasmata is good for Jingliukang Cataplasmata.