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Expression of miRNA-21 in papillary thyroid carcinoma

Xiubo Lu

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Abstract

Objective To observe the expression of miRNA-21 in papillary thyroid carcinoma (PTC) and adjacent tissues,and to explore the role of miRNA-21 in PTC.Methods The miRNA-21 was measured by micRNA chip technology in 3 cases,and the miRNA-21 was quantified by real-time fluorescence quantitative polymerase chain reaction (PCR) with TaqMan? MicroRNA Assays in 20 cases.Results The expression of miRNA-21 was up-regulated in PTC tissues as compared with than in adjacent non-tumor tissues by micRNA chip technology (P ＜ O.01 ).The mean expression level of miRNA-21 was (3.97 ± 1.29 ) times higher in PTC tissues than that in adjacent non-tumor tissues ( P ＜ 0.05 ).Conclusion The increased expression of miRNA-21 may play an important role in the pathogenesis of PTC.The results from micRNA chip technology and real-time fluorescence quantitative PCR with TaqMan? microRNA Assays in micRNA-21 are consistent. Key words: micRNA chip;  Papillary thyroid carcinoma;  miRNA-21

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What this paper is about

Objective To observe the expression of miRNA-21 in papillary thyroid carcinoma (PTC) and adjacent tissues,and to explore the role of miRNA-21 in PTC.Methods The miRNA-21 was measured by micRNA chip technology in 3 cases,and the miRNA-21 was quantified by real-time fluorescence quantitative polymerase chain reaction (PCR) with TaqMan? MicroRNA Assays in 20 cases.Results The expression of miRNA-21 was up-regulated in PTC tissues as compared with than in adjacent non-tumor tissues by micRNA chip technology (P ＜ O.01 ).The mean expression level of miRNA-21 was (3.97 ± 1.29 ) times higher in PTC tissues than that in adjacent non-tumor tissues ( P ＜ 0.05 ).Conclusion The increased expression of miRNA-21 may play an important role in the pathogenesis of PTC.The results from micRNA chip technology and real-time fluorescence quantitative PCR with TaqMan? microRNA Assays in micRNA-21 are consistent. Key words: micRNA chip;  Papillary thyroid carcinoma;  miRNA-21

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Available abstract

Objective To observe the expression of miRNA-21 in papillary thyroid carcinoma (PTC) and adjacent tissues,and to explore the role of miRNA-21 in PTC.Methods The miRNA-21 was measured by micRNA chip technology in 3 cases,and the miRNA-21 was quantified by real-time fluorescence quantitative polymerase chain reaction (PCR) with TaqMan? MicroRNA Assays in 20 cases.Results The expression of miRNA-21 was up-regulated in PTC tissues as compared with than in adjacent non-tumor tissues by micRNA chip technology (P ＜ O.01 ).The mean expression level of miRNA-21 was (3.97 ± 1.29 ) times higher in PTC tissues than that in adjacent non-tumor tissues ( P ＜ 0.05 ).Conclusion The increased expression of miRNA-21 may play an important role in the pathogenesis of PTC.The results from micRNA chip technology and real-time fluorescence quantitative PCR with TaqMan? microRNA Assays in micRNA-21 are consistent. Key words: micRNA chip;  Papillary thyroid carcinoma;  miRNA-21

Key concepts: TaqMan, microRNA, Thyroid carcinoma, Real-time polymerase chain reaction, Molecular biology, Pathology, Polymerase chain reaction, Cancer research

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