2012•Experimental and Laboratory MedicineRequires access
Expression and significance of miRNAs in renal clear cell carcinoma tissues
Cui Su-ping
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Abstract
Objective To study miRNAs expression in renal clear cell carcinoma and its clinical significance.Methods The expression levels of miRNA-20b,miRNA-21,miRNA-34a,miRNA-210,miRNA-141,miRNA-200c,miRNA-200b,miRNA-514 and miRNA-532-5p in renal clear cell carcinoma tissues and their corresponding adjacent tissues were analyzed with qRT-PCR;their relationships with clinical pathological features were analyzed with statistical method.Results Compared with adjacent tissue,miRNA-21,miRNA-34a,and miRNA-210 were high-expressed in renal cell carcinoma while miRNA-141 and miRNA-200c were low-expressed(P0.05),the expression levels of miRNA-20b,miRNA-200b,miRNA-514 and miRNA-532-5p kept unchanged.The expression level of miRNA-34a increased with the tumor grade.Conclusion miRNA-21,miRNA-34a,miRNA-210,miRNA-141 and miRNA-200c were differentially expressed in renal clear cell carcinoma;they may be used as potential diagnostic and therapeutic targets for renal cell carcinoma.