2018•国际医药卫生导报Requires access
Mechanism of PTEN protein gene and invasion and metastasis of ovarian cancer
Yang Zhang, Yan Sun, Hong-Jin Jiang
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Abstract
Objective
To investigate the mechanism of PTEN protein gene and invasion and metastasis of ovarian cancer.
Methods
40 cases with ovarian cancer and 40 patients with benign ovarian cancer in our hospital From January 2016 to December 2016 were enrolled in this study. The expression of PTEN was compared between the two groups, the expression of PTEN in patients with ovarian cancer with and without lymph node metastasis was compared.
Results
The positive rate of PTEN expression in malignant tumor group was 87.5%, and that in benign tumor group was 37.5%, the positive rate of PTEN expression in the observation group was significantly higher than that in the benign tumor group (P<0.05). The positive rate of PTEN expression in patients with lymph node metastasis was 90.0%, that in patients without lymph node metastasis was 15.0%, the positive rate of PTEN expression in lymph node metastasis group was significantly higher than that in non-lymph node metastasis group (P<0.05).
Conclusion
PTEN protein gene expression is significantly reduced in ovarian cancer patients, especially patients with ovarian cancer with lymph node metastasis.
Key words:
PTEN protein gene; Ovarian cancer; Invasion; Metastasis