2006•Harbin Yike Daxue xuebaoRequires access

Relationship between the expression of p53,PTEN protein and the lymphatic metastasis of laryngeal cancer

Xianyi Yao

Abstract

Objective To investigate the roles of p53 and PTEN genes in cervical lymph node metastasis of laryngeal cancer.Methods Expressions of p53 protein and PTEN protein were studied by immunohistochemical staining in the 42 specimens of laryngeal carcinomas.Results The positive expression of p53 and PTEN were 47.62% and 57.14% respectively,p53 and PTEN positive expression were related to with lymph node metastasis.The p53 positive and PTEN negative laryngeal arcinomas in patients with cervical lymph node metastasis were more frequently observed than that in patients without metastasis.Conclusion Laryngeal cancer with p53 positive and PTEN negative expression is prone to occur cervical lymph node metastasis.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: PTEN, Immunohistochemistry, Metastasis, Medicine, Lymph node metastasis, Cancer research, Laryngeal Neoplasm, Pathology