Study of treatment switching from premixed insulin to glargine combined with oral antidiabetic drugs of patients with type 2 diabetic

Objective To evaluation the efficacy,safety and treatment satisfaction of glargine plus oral medications(OADs) switching from premixed insulin on patients with type 2 diabetic.Methods Forty-three patients with type 2 diabetes were enrolled into our study.All patients were treated with twice-daily premixed insulin therapy for at least 3 months with or without OADs and their glycosylated haemoglobin(HbA1c) were less than 10.0％.The aim of OADs treatment was FBG ≤ 5.6 mmol/L Results Thirty-six cases were performed a 16 weeks follow-up and no one lost.After 4 months OADs treatment,the levels of fasting blood-glucose(FBG),2 h postprandial blood glucose (PBG),and HbAlc were similar with before OADs treatment (P ＞0.05).However,the dosage of insulin decreased from (23.8 ± 6.0) U/d before treatment to (9.6 ± 4.0) U/d after treatment,and the different was significant (t =13.59,P ＜ 0.01).Body mess index (BMI) also significant decreased from (24.4 ±2.9) kg/m2 to (23.8 ±2.8) kg/m2 (t =3.25,P ＜0.05).During follow-up periods,15 patients were with hypoglycemia for 30 times and the rate of hypoglycemia was 41.7％ (15/36).Hypoglycemia can be recovery without others help,and small amount of feeding after remission.No patient with hypoglycemia withdrawn from the study.The overall satisfaction rate after OADs treatment was 72.2％ (26/36),higher than that before treatment (36.1％ (13/36)),x2 =6.26,P ＜0.05).Conclusion When patients' HbA1c less than 7.0％,the glargine insulin plus OADs treatment switching from premixed insulin can effectively control the level of blood glucose,reduce insulin dosage and times of injection,get less weight gain,and increase treatment satisfaction. Key words: Diabetes mellitus type 2 ;  Glargine insulin ;  Premixed insulin