Analysis of Efficacy and Safety of the Treatment of Insulin Glargine Combined with Oral Hypoglycemic Drugs for Type 2 Diabetic Patients

Objective Evaluation of the efficacy and safety of the treatment insulin glargine combined with OADs for type 2 diabetic patients with poor glycemic control using premixed insulin therapy.Methods 50 cases of type 2 diabetic patients were randomly divided into treatment group(convert premixed insulin into insulin glargine plus OADs)(n=30) and control group(continue to use the premixed insulin plus OADs)(n=20),all groups were adjusted the dosage of insulin and OADs based on the levels of blood glucose.After 12 weeks the index of FBG、2hPG、HbA1c、BMI and the incidence of hypoglycemia during the test were compared in two groups.Results Compared with those before treatment,HbA1c、FBG、2hPG of the two groups have declined(P all 0.01);the treatment group has no significant change in BMI(P0.05).Compared with the control group,FBG、lunch 2hPG and HbA1c of the treatment group is lower(P all0.01);BMI of treatment group is lower(P0.01);the incidence of hypoglycemia during the test of the treatment group is lower(P0.01).Conclusion The treatment of insulin glargine combined OADs for poor glycemic control in type 2 diabetic patients using premixed insulin,can significantly improve the levels of FBG and HbA1c,do not increase body weight,be simple,and can greatly reduce the risk of hypoglycemia.