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The detection of DNA damage of rat organs caused by T-2 toxin with SCGE

卜黎明, Ning Liu, 程绍辉, 孙殿军

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Abstract

目的探求T-2毒素在体内的毒作用靶器官以及对T-2毒素中毒的敏感监测方法和生物标志.方法采用单细胞凝胶电泳(SCGE)技术及动物实验.结果在所测的器官中,以大鼠肝脏对T-2毒素最为敏感,其次为外周血淋巴细胞(PBL).结论外周血淋巴细胞的DNA损伤可以作为机体T-2毒素中毒的生物标志进行探索.

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What this paper is about

目的探求T-2毒素在体内的毒作用靶器官以及对T-2毒素中毒的敏感监测方法和生物标志.方法采用单细胞凝胶电泳(SCGE)技术及动物实验.结果在所测的器官中,以大鼠肝脏对T-2毒素最为敏感,其次为外周血淋巴细胞(PBL).结论外周血淋巴细胞的DNA损伤可以作为机体T-2毒素中毒的生物标志进行探索.

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Available abstract

目的探求T-2毒素在体内的毒作用靶器官以及对T-2毒素中毒的敏感监测方法和生物标志.方法采用单细胞凝胶电泳(SCGE)技术及动物实验.结果在所测的器官中,以大鼠肝脏对T-2毒素最为敏感,其次为外周血淋巴细胞(PBL).结论外周血淋巴细胞的DNA损伤可以作为机体T-2毒素中毒的生物标志进行探索.

Key concepts: Toxin, DNA damage, DNA, Biology, Cell biology, Molecular biology, Computational biology, Genetics

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