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The detection of DNA damage of rat organs caused by T-2 toxin with SCGE

Shaohui Cheng

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Abstract

Objective To explore the sensitive organ of T-2 poisoning in rat, and the effective biomonitoring method.Methods Single Cell Gel Electrophoresis (SCGE).Results The results showed that among the examined organs the liver is the most sensitive to T-2 toxin, the second is Peripheral Blood Lymphocytes (PBL).Conclusions The DNA damage of Peripheral Blood Lymphocytes can be a possible biomarker for T-2 poisoning.

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What this paper is about

Objective To explore the sensitive organ of T-2 poisoning in rat, and the effective biomonitoring method.Methods Single Cell Gel Electrophoresis (SCGE).Results The results showed that among the examined organs the liver is the most sensitive to T-2 toxin, the second is Peripheral Blood Lymphocytes (PBL).Conclusions The DNA damage of Peripheral Blood Lymphocytes can be a possible biomarker for T-2 poisoning.

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Available abstract

Objective To explore the sensitive organ of T-2 poisoning in rat, and the effective biomonitoring method.Methods Single Cell Gel Electrophoresis (SCGE).Results The results showed that among the examined organs the liver is the most sensitive to T-2 toxin, the second is Peripheral Blood Lymphocytes (PBL).Conclusions The DNA damage of Peripheral Blood Lymphocytes can be a possible biomarker for T-2 poisoning.

Key concepts: Toxin, DNA damage, Peripheral blood, Gel electrophoresis, Biomarker, Molecular biology, Biology, DNA

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