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The observation of DNA damage caused by HT-2 toxin with SCGE

Bu Li

Open publisher page 1 citations

Abstract

Objective To detect the DNA damage of Hela cells caused by HT 2 toxin.Methods We conducted this study with MTT and Single Cell Gel Electrophoresis (SCGE).Results The results showed that HT 2 toxin can damage the cell DNA,and the dose effect relationship is founded that with the dose increasing (800 ng/ml to 1600 ng/ml),the degree of DNA damage is increasing,the tail length are (28.4±5.67)μm and (55.8±10.47)μm,respectively.Conclusions HT 2 toxin can cause the cell DNA damage.

About this research paper

What this paper is about

Objective To detect the DNA damage of Hela cells caused by HT 2 toxin.Methods We conducted this study with MTT and Single Cell Gel Electrophoresis (SCGE).Results The results showed that HT 2 toxin can damage the cell DNA,and the dose effect relationship is founded that with the dose increasing (800 ng/ml to 1600 ng/ml),the degree of DNA damage is increasing,the tail length are (28.4±5.67)μm and (55.8±10.47)μm,respectively.Conclusions HT 2 toxin can cause the cell DNA damage.

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Available abstract

Objective To detect the DNA damage of Hela cells caused by HT 2 toxin.Methods We conducted this study with MTT and Single Cell Gel Electrophoresis (SCGE).Results The results showed that HT 2 toxin can damage the cell DNA,and the dose effect relationship is founded that with the dose increasing (800 ng/ml to 1600 ng/ml),the degree of DNA damage is increasing,the tail length are (28.4±5.67)μm and (55.8±10.47)μm,respectively.Conclusions HT 2 toxin can cause the cell DNA damage.

Key concepts: Toxin, DNA damage, HeLa, Gel electrophoresis, DNA, Molecular biology, Chemistry, Cell

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