Effect of endometrium minimally invasive pretreatment on non-pregnant PCOS patients who are on ovulation induction treatment

Objective To observe the therapeutic effect of endometrium minimally invasive pretreatment on non-pregnant PCOS patients who are on ovulation induction treatment. Methods According to the digital meter method, divided 66 non-pregnant PCOS patients who were with abnormal endometrial echoes or abnormal thickening by ultrasound in follicular phase in natural periodwith into testing group(33 cases)and control group(33 cases). All patients were treated with drospirenone and ethinylestradiol tablets treatment for 3 to 6 cycles,and then with clomiphene citrate(CC)for induction of ovulation. In the testing group,endometrium microresecting was given by disposable uterine cavity tissue suction tube device within 3~5days after menstrual onset. Patients in the control group were not performed with endometrium microresecting. All patients of the two groups were given estrogen and progesteroneas well as detection of ovarian folicle and endom etrium with B-modeult rasonography. Results Intimal thickness in the testing group was(8.78±1.56)mm, the pregnancy rate was 36.36%and the abortion rate was 16.67%,there was no obvious pain and unwell during the operation and the patients were free from infection. Intimal thickness in the testing group was(6.32±0.74)mm,the pregnancy rate was 24.24%and the abortion rate was 12.50%. There were significant differences between the two groups of endometrial thickness, pregnancy rate(t=8.184,χ2=4.60,all P<0.05). Conclusion Endometrium microresecting by endometrial sampling device can increase the endometrium, thickness and the pregnancy rate, and at the same time it doesnot increase the rate of early spontaneous abortion. And it is easy to perate, convenient, less trauma, less pain, easy to acceptand and some other advantages, it has better clinical application value, so it deserves to be applied in basic hospital. Key words: Abnormality endometrium; Endometrium microresecting; Polycystic ovary syndrome; Induetion of ovulation