Zhen Zeng, Chunxiang Ma
Abstract
炎症性肠病（IBD）主要与遗传易感性、环境、肠道菌群和免疫失调等因素相关。遗传因素在IBD发病机制中发挥着十分重要的作用。本文将对涉及细菌识别、IL23/Th17信号途径、自噬、上皮屏障的IBD易感基因的研究现状及进展进行阐述。
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炎症性肠病（IBD）主要与遗传易感性、环境、肠道菌群和免疫失调等因素相关。遗传因素在IBD发病机制中发挥着十分重要的作用。本文将对涉及细菌识别、IL23/Th17信号途径、自噬、上皮屏障的IBD易感基因的研究现状及进展进行阐述。
Key concepts: Inflammatory bowel disease, Ulcerative colitis, Gene, Disease, Genetics, Biology, Medicine, Immunology