Effect of intensive atorvastatin therapy on coronary blood flow after percutaneous coronary intervention of unstable angina patients with diabetes

Objective To investigate the effect of intensive atorvastatin therapy on coronary reperfusion of patients with unstable angina and diabetes undergoing percutaneous coronary intervention (PCI) and its safety.Methods One hundred and thirty-seven unstable angina patients with diabetes were underwent percutaneous coronary intervention in Zhumadian Central Hospital from July 2011 to July 2013.Patients were randomly divided into regular and intensive groups.Patients in regular group (n =59) were received atorvastatin 20 mg/d after admission and in intensive group (n =78) were received atorvastatin 80 mg 2 h before PCI beside atorvastatin 20 mg/d.The information of thrombolysis in myocardial infarction flow grade and perioperative myocardial infarction(MI) were recorded.The level of liver enzyme,serum creatinine and creatine kinase were measured.Results Compared with the regular group,the postoperative incidence of no reflow,slow flow and perioperation MI was lower in intensive group.The rate of MI in intensive group was 5.1％ (4/78),lower than that in regular group (17.0％ (10/59) ;x2 =5.44,P =0.02)).There was no significant difference in terms of liver enzymes,serum creatinine and creatine kinase between two groups (P ＞ 0.05).Multiple factors correlation analysis showed that after adjusted gender,age,smoking,hyperlipidemia,lesions and important branch after the involvement of expansion and other factors,intensive statin therapy was the independent prognostic factor to avoid the occurrence of no reflow,slow flow and peri operation period of myocardial infarction.Conclusion The intensive atorvastatin therapy can improve coronary perfusion without increasing the risk of side-effect for unstable angina patients with diabetes undergoing PCI. Key words: Unstable angina;  Diabetes;  Atorvastatin