Effects of large dose of atorvastatin in patients with unstable angina after percutaneous coronary intervention

Objective To investigate the effects and safety of taking large dose (80 mg)of atorvastatin before percutaneous coronary intervention(PCI) on postoperative myocardial damage in patients with unstable angina.Methods One hundred and sixty patients who underwent PCI in the past three years in Jiaozuo people's hospital were selected,they were randomly divided into intensive group and control group,80 patients in each group.Patients in both groups were treated with conventional therapy of PCI,and the patients in intensive group were given large dose of atorvastatin(80 mg,6-12 hours before operation).The changs of noreflow occurrence,isoenzymes of creatine kinase MB(CK-MB) and troponin T(cTNT) were observed.Results The incidence of no-reflow occurrence in intensive group was significantly lower than that in control group (1.3％ vs 8.8％,P ＜ 0.05).The level of CK-MB and cTNT in intensive group after operation were lower than that of control group (P ＜ 0.05).Conclusions Taking large dose of atorvastatin is safe and may reduce incidence of no re-flow and postoperative myocardial damage. Key words: Atorvastatin;  Unstable angina;  Percutaneous coronary intervention;  No re-flow