Application progress of neurone specific enolase in neonatal brain injury

In recent years, as a specific marker of nervous system damage, NSE has received attentions of the neonatal clinical doctors increasingly; when neurons are damaged, neurone specific enolase(NSE)will be released into the cerebrospinal fluids and enters the blood by passing through the blood brain barrier, thus NSE has significant value in diagnosing and the prognosis of neonatal brain injury.However, dispute exists on the dynamic change process of NSE in neonatal fluids when they are incurred with brain injury, moreover, there is no uniform standard of the threshold value for predicting brain injury and prognostic judgment.This paper mainly discusses the progress of NSE in neonatal brain injury in recent years. Key words: Neurone specific enolase; Neonatus; Brain injury