Effect of Catharsis on Levels of Plasma Motilin and Vasoactive Intestinal Polypeptide of Rats with Constipation by Outlet Obstruction

Objective To study the effect of catharsis method on the levels of plasma MTL and VIP of OOC rats,and investigate the rationality of purgation and lubricant purgation treating OOC. Methods The models of constipation by outlet obstruction were made by constricting the rectum of rats partly, and taking out stitches in vitro to relieve obstruction.Using the Da Cheng Qi Tang (DCQT) and Ma Ren Wan (MRW) as carrieres to object the effect of catharsis method on the levels of plasma MTL and VIP of rats and contrast histopathologie severity of colitis. Results The inflammatory reaction of intestinal mucous was relieved significantly in DCQT group and MRW group, and levels of plasma MTL were raised significantly than normal group(P＜0.05). The levels of plasma VIP went down significantly in model group, DCQT group and MRW group than in normal group(P＜0.01). Conclusion Purgation and lubricant purgation could relieve the inflammatory reaction of intestinal mucosa of OOC rats, influence the levels of plasm MTL and VIE and promote defecation.But we must consider using them exactly. Key words: Constipation by outlet obstruction (OOC) : Motilin (MTL) : Vasoactive intestinal peptide (VIP):DACHENQITANG (DCQT) ;  MARENWAN (MRW) ;