The effect of finasteride on the expression of VEGF, Fit-1 and the MVD in benign prostatic hyperplasia

Objective：To study the effect of finasteride on the expression of VEGF,Flt-1 and the MVD in benign prostatic hyperplasia. Methods：BPH cases was divided into 2 groups; finaster/de treatment group and non.Immtmohistochemical staining（S-P） was used to examine MVD and the expression of VEGF,Flt-1 in BPH. Results：The positive rate of VEGF in the treatment group was 68.4%; the positive rate of VEGF in the non treatment group was 57%. Statistic significance existed between the two groups （P〈0.05）. The expression of Flt-1 was all positive . MVD was 6.89±2.54 in finasteride treated group and 9.17±3.63 in nontreatment group. Statistic significance of both VEGF and MVD expression existed in the two groups（P〈0.05）. Conclusions： Finasteride could downregulate the synthesis and expression of VEGF, which inhibit the angiogenesis in BPH, but has less impact on Flt-1. Key words: Benign prostatic hyperplasia;  Vascular endothelial growth factor; Fins-like tyrosine kinase receptor;  Microvessel density ; Immunohistochemistry;  Finasteride.