Comparative effect of sufentanil with different concentrations in thyroid surgery

Objective To investigate the effects of sufentanil with different concentrations in patients control the sedative and analgesic in thyroid surgery. Methods Sixty patients with thyroid surgery were randomly equally divided into three groups before thyroidectomy: group A, group B and group C were respectively given 0.1, 0.2 and 0.3 μg/kg sufentanil by intravenous injection. At the infusion, 0.1 μg/(kg·h)sufentanil was administered. The mean arterial pressure (MAP), heart rate (HR), the pulse of oxygen saturation (SpO2), respiratory rate (RR), the sedation score and visual analogue scales (VAS) at the time of incision (T1), upside pulling thyroid (T2) and seam skin (T3) were recorded. Results At T1 and T2,Ramsay Ⅳ level in group B (13, 14 cases) and group C (14, 15 cases) were more than those in group A(7,10 cases)(P 0.05). VAS in group B and group C was significantly lower than that in group A (P< 0.05). AtT2, the MAP and HR in group A compared with T1 and T3, there was significant difference (P< 0.05). At T1 and T2 the MAP and HR in group B and group C compared with group A, there was significant difference (P < 0.05). Conclusion Sufentanil can be safe and effective for thyroid surgery and sedation analgesia, with loading dose of 0.2 μg /kg, followed by 0.1 μg/(kg ·h) continuous infusion better effect. Key words: Sufentanil;  Thyroid gland;  Analgesia