Application of Sufentanil Combined with Butorphanol Patient-controlled Intravenous Analgesia in Elderly Patients Underwent Lumbar Internal Fixation

OBJECTIVE:To observe therapeutic efficacy and safety of sufentanil combined butorphanol patient-controlled intravenous analgesia(PCIA)in elderly patients underwent lumbar internal fixation. METHODS:60 elderly patients underwent lumbar internal fixation were randomly divided into sufentanil group(group S)and sufentanil combined with butorphanol group(group B). After induction,group B was given butorphanol 4 mg+ sufentanil 100 μg+0.9% Sodium chloride injection 100 ml;group S was given sufentanil 100 μg+0.9% Sodium chloride injection 100 ml;2 groups were given loading-amount of initial dose 5 ml,maintenance dose 0.04 ml/kg,single loading-amount 5 ml and locking time 15 min for PCIA. HR,MBP,RR,SPO2,VAS,Ramsay sedation score and ADR of 2 groups were observed at the end of operation(T0),1h after operation(T1),4 h after operation(T2),12 h after operation(T3),24 h after operation(T4)and 48 h after operation(T5). RESULTS:HR,MBP and RR of 2groups at T1-T5were significantly lower than at T0. HR and MBP of group B were significantly lower than those of group S at T1-T5,and RR of groups were significantly lower than those of group S at T1-T3(P0.05);there was no statistical significance in SPO2 between 2 groups at T0-T5(P0.05). VAS of 2 groups at T1-T5were significantly higher than at T0,that of group S was lower than that of group B(P0.05). Ramsay sedation score of group B at T1-T4were significantly higher than at T0,that of group B at T1-T5was higher than that of group S(P0.05). The incidence of ADR in group S was significantly higher than in group B(P0.05). CONCLUSIONS:Sufentanil combined with butorphanol PCIA have good analgesia effect and safety in elderly patients underwent lumbar internal fixation.