Application of postoperative analgesia with sufentanil or fentanyl in neonates

Objective To evaluate the efficacy of postoperative analgesia with sufentanil or fentanyl in neonates.Methods Ninety neonates underwent surgery were randomly divided into 3 groups with 30 cases each.Group A and B recived continuous intravenous infusion of sufentanil(0.025 μg·kg-1·h-1) and fentanly(0.25 μg·kg-1·h-1),respectively.Control group(C) was given no analgesia.Heart rate(HR),blood pressure(BP),respiratory rate(RR),oxygen saturation(SaO2),pain score(CRIES),neonatal behavioral neurological assessment(NBNA)were monitored and assessed during analgesia,and urinary S100β protein concentration of all neonates was measured at 12 h(T1),24 h(T2),48 h(T3) and 96 h(T4) after operation.Results Compared to group C,the CRIES was increased significantly at T1 to T4in group A and B(P0.05).The CRIES was higher significantly in group B than that in group A at T4(P0.05).The NBNA of group A and B was higher significantly at T1 to T4 than that of group C(P0.05).Urinary S100β protein concentration of group C was higher than that of group A at T1 to T4(P0.01),which was higher in group B than that in group A at T3.PONV happened in 2 cases in group B and 5 cases in group C.There were no neonates with respiratory depression in three groups.Conclusion Neonates postoperative analgesia with intravenous sufentanil(0.025 μg·kg-1·h-1) or fentanyl(0.25 μg·kg-1·h-1) is effective and safe.