Risk factors influencing prognosis of patients with sepsis

Objective To explore the risk factors of prognosis in patients with sepsis. Methods 106 patients with sepsis admitted to our department from June, 2017 to June, 2019 were included in the study. According to their prognosis during the one-month follow-up after discharge, they were divided into a death group (28 cases) and a survival group (78 cases). The levels of serum procalcitonin (PCT), C-reactive protein (CRP), and fasting blood glucose (FBG) were compared between the two groups; and the risk factors affecting the prognosis were analyzed. Results On the first day, the serum level of PCT was lower in the survival group than in the death group [(4.22±1.25) ng/ml vs. (8.56±3.34) ng/ml], with a statistical difference (P 0.05). The age, the scores of SOFA and APACHE Ⅱ, and the serum levels of PCT and CRP were lower in the survival group than in the death group [(60.13±10.25) years vs. (69.25±8.27) years, (4.81±2.82) vs. (7.94±4.01), (17.85±2.33) vs. (60.57±10.65), (4.45±1.81) ng/ml vs. (8.26±2.12) ng/ml, and (68.25±15.62) mg/L vs. (158.68±45.53) mg/L; all P<0.05)]. The logistic analysis showed that age SOFA score, APACHE score, PCT, and CRP were the risk factors of the prognosis of the patients (all P<0.05). Conclusion The increase of serum PCT level can reflect the severity of sepsis to a certain extent, so it can be used as an important indicator for predicting the prognosis of sepsis. At the same time, combined with serum CRP, SOFA score, APACHE II score, etc., it can further improve the prediction of sepsis prognosis. Key words: Sepsis; Serum procalcitonin; Prognosis; Risk factors