Value of procalcitonin and SOFA score in the early diagnosis and prognosis of sepsis

OBJECTIVE To explore the value of serum procalcitonin(PCT) and SOFA score in the early diagnosis and prognosis of sepsis.METHODS According to the severity of disease,107 patients of critical illness patients who were admitted in ICU were divided into four groups,including 31 patients of the SIRS group,26 patients of the sepsis group,25 patients of the severe sepsis group,and 25 patients of the septic shock group,and at the same time 30 healthy people were selected and were also divided into the survivor group and the death group according to the prognosis.The levels of serum PCT,CRP,and the SOFA scores were detected and compared.RESULTS The level of the serum PCT,CRP and the SOFA scores were respectively(1.76±0.36) μg/L,(53.42±12.44) mg/L,and(3.54±1.24) points in the SIRS group,(2.25±0.74) μg/L,(87.25±13.27) mg/L,and(6.75±2.37) points in the mile sepsis group,(5.54±1.43) μg/L,(91.73±16.63) mg/L,and(8.49±2.83) in the severe sepsis group,and(8.82±2.54) μg/L,(112.74±23.57) mg/L,and(10.26±3.37) points in the septic shock group,which were significantly increased as compared with the control group,and with the severity aggravating,the serum PCT and the SOFA scores were increased separately(P0.05).The levels of serum PCT,CRP and the SOFA scores of the three sepsis groups were significantly higher than those of the SIRS group,while the difference in the level of CRP among the three sepsis groups was not statistically significant.The serum PCT level and the SOFA score of the death group were respectively(7.63±2.68) μg/L and(9.06±2.26) points,significantly higher than(2.37±1.03) μg/L and(5.38±1.87) points of the survivor group(P0.05),however,the difference in the level of CRP between the two groups was not statistically significant;the logistic regression analysis indicated that the serum PCT level and the SOFA score were the independent risk factors of the sepsis(OR=5.132,7.369,P0.05).CONCLUSION The serum PCT levels and the SOFA score can be served as an early diagnosis indicator of sepsis,and it is of great significance in the evaluation of severity and prognosis of the patients with sepsis through the SOFA score combined with the detection of PCT level.