Diagnostic value of CEA, AFP, CA19-9 and CA125 in malignancy diseases of digestive system

Objective To investigate the clinical diagnostic significance of serum CEA,AFP,CA19-9 and CA125 in patients with tumors of digestive system.Methods Electrochemical luminescence immunoassay (ECLIA) method was used to detect serum CEA,AFP,CA19-9 and CA125 levels in 260 patients with tumors of digestive system,114 patients with digestive system disease and 80 nomal healthy people.The sensitivity,specificity,accuracy and positive predictive value (PPV)of 4 biomarkers in tumors of digestive system,as well as their combined measurement effect was evaluated.Results The positive rate of serum CEA,AFP,CA19-9 and CA125 to diagnose tumors of digestive system was 33.08％,26.92％,33.85％ and 22.31％ respectively,but the combined examination(CEA + AFP + CA19-9 + CA125) was 64.62％.The specificity of CEA,AFP,CA19-9 and CA125 was 74.31％,98.08％,84.21％ and 76.32％ respectively and 54.39％ in combination.The accuracy increased from 53.2％ (CEA),44.12％ (AFP),49.2％ (CA19-9) and 38.77％ (CA125) to 64.17％ (CEA +AFP + CA19-9 +CA125).The PPV of CEA,AFP,CA19-9 and CA125 was 89.47％ 、88.61％ 、83.02％ and 77.33％ respectively and 80.00％ in combination.Conclusions With combined determination of CEA,AFP,CA19-9 and CA125,the positive rate and accuracy are enhanced,which is vital importance in the early diagnosis of digestive system tumors. Key words: Tumor markers ;  Cancer embryo antigen ;  Alpha fetal protein ;  Carbohydrate antigen 19-9 ;  carbohydrate antigen 125 ;  Tumors of digestive system