2005•Zhongguo jiceng yiyaoRequires access

A study of expression and relation between matrix metalloproteinase 9 mRNA and vascular endothelial growth factor in gastric carcinoma

谢忠, 林翔, 冯华扬, 谢杰荣, 温继育, 冯丽萍

Abstract

目的探讨胃癌中血管内皮生长因子(VEGF)和基质金属蛋白酶-9(MMP-9)的表达与胃癌生物学行为的关系.方法应用免疫组织化学SP法检测70例胃癌组织及38例远癌胃黏膜中VEGF与MMP-9的表达.结果 VEGF在胃癌中的表达(61.4%)显著高于远癌胃黏膜的表达(31.6%)(P＜0.01),且与淋巴结转移呈正相关(P＜0.01),而与年龄、性别、组织分化程度及肿块浸润深度无关(均P＞0.05).MMP-9在胃癌中的表达(68.6%)显著高于远癌胃黏膜的表达(39.5%)(P＜0.01),且与淋巴结转移呈正相关(P＜0.05),而与年龄、性别、组织分化程度及癌组织浸润深度无关(均P＞0.05).结论 MMP-9、VEGF在肿瘤浸润、转移中起重要作用;其共位表达有助于判断胃癌预后。

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Key concepts: Medicine, Matrix metalloproteinase, Gastric carcinoma, Vascular endothelial growth factor, Messenger RNA, Matrix metalloproteinase 9, Cancer research, VEGF receptors