Fiuvoxamine and maprotiline in the treatment of depression and anxiety

Objective To investigate the efficacy and safety of fluvoxamine in the treatment of patients with refractory depression and anxiety.Methods Sixty -nine patients with refractory depression and anxiety were randomly assigned to 6 weeks treatment with fluvoxamine (n =35 )or maprotiline (n =34 ) and changes from baseline in the Hamilton Rating Scale for Depression( HAMD - 17),total scores of the two groups,and Treatment Emergent Symptom Scale (TESS)were compared at 1 week before treatment and 1,2,4,6 weeks after treatment.Results The significant efficacy rates of fluvoxamine group was 78％,while that was 75％ in the maprotiline group.There were less side effects in the fluvoxamine group than maprotiline group.Conclusions Fluvoxamine is better than maprotiline in the treatment of refractory depression and anxiety,It shows better efficacy and less side effects.It is beneficial to improve the herapeutic compliance of depressive patients. Key words: Depression; Anxiety; Efficacy; Fluvoxamine; Maprotiline