A control study of fluvoxamine and maprotiline in the treatment of depression and anxiety

Objective:To investigate the efficacy and safety of fluvoxamine in the treatment of patients with refractory depression and anxiety.Methods:A total of patients with refractory depression and anxiety were randomly assigned to 8 weeks treatment with fluvoxamine(n=35) or maprotiline(n=34) and changes from baseline in the Hamilton Rating Scale for Depression(HAMD-17),total scores of two groups,and Treatment Emergent Symptom Scale(TESS) were compared at 1 week before treatment and 1,2,4,8 weeks after treatment.Results:The significant efficacy rates of Fluvoxamine group was 78%,while that was 75% in the maprotiline group.There were less side effects in the Fluvoxamine group than the other group.Conclusion:Fluvoxamine is better thanmaprotilinein the treatment of refractory depression and anxiety,it shows better efficacy and less side effects.It is beneficial to improve the trerapeutic compliance of depressive patients.