Observation On the Curative Effect of Tangshentongbao Decoction Combined Benazepril on 31Cases of Diabetic Nephropathy in Clinical Stage

Objective To assess the protective effect of Tangshentongbao decoction combined benazepril on renal function of the patients with diabetic nephropathy(DN) in clinical stage and to make a effective contrast to the therapy with western medicine. Methods 62 patients with DN in clinical stage were randomly divided into a control group and a treatment group, with 31 patients in each group. Both groups were supplied with the same food, adopted glucose control therapy and symptoms orientated treatment. On these basis, the treatment group was administered with Tangshentongbao decoction combined benazepril, and the control group was taken kallikrein enteric tablet combined benazepril. The therapeutic courses for both groups were 8 months. The changes of symptoms and physical signs, 24-hour urinay protein (24hUpro), serum cteatimine (SCr), serum creatinine clearance erate (CCr) , blood urea nitrogen (BUN), triglyceride (TG), cholesterd (CHO) and low density lipoprotein-cholesterol (LDL-C)of the two groups were separately assessed. Results 24hUpro, SCr, TG, CHO and LDL-C of treated group were all reduced after the treatment (P<0.01 or P <0.05), showing significant difference compared with the control group. Conclusion 24hUpro and SCr of patients with DN in clinical stage can be evidently reduced by Tangshentongbao decoction, and the effect of reducing blood lipid is remarkable better than western medicine alone. Key words: Diabetic nephropathy in clinical stage;  Kidney function;  Blood lipid;  Tangshentongbao decoction;  Benazepril