Effect of Ulinastatin in the level of plasma inflammatory cytokines, CRP, IL-8, IL-10 and TNF-α, of patients with severe asthma

Objective To discuss the effect of ulinastatin in the level of plasma inflammatory cytokines, C-reactive protein (CRP), IL-8, IL-10 and tumor necrosis factor (TNF-α), of patients with severe asthma. Methods The paper included 90 patients with severe asthma were randomly divided into the experimental group and the control group, who visited hospital to seek medical treatment from March 2016 to March 2017.Two groups of patients were given routine treatment, such as oxygen, anti-inflammatory, inhalation, hormone therapy, experimental group treated with 10 days.of ulinastatin in the treatment.collected peripheral blood samples, detected the level of CRP, IL-10, TNF-α and other inflammatory cytokines in plasma by adopting enzyme linked immunosorbent assay (ELISA) and scatter turbidimetry.Analysis of changes of inflammatory cytokines in plasma after treatment with ulinastatin in patients with severe asthma treatment. Results Two groups of patients after treatment, the level of CRP, IL-8, TNF-α were decreased significantly compare with before treatment (P<0.05), and the level of IL-10 increased significantly compared with those before treatment (P<0.05). After treatment, the level of CRP, IL-8, TNF-α with experimental group were lower than the control group (P<0.05), and the level of IL-10 were higher than the control group (P<0.05). Conclusions Effect of ulinastatin on the treatment of patients with severe asthma effectively, can significantly reduce the inflammatory cytokines level of CRP, IL-8, TNF-α, and elevated the inflammatory cytokines level of IL-10, can be used as an adjunctive therapy in drug treatment in patients with severe asthma. Key words: Severe asthma; Ulinastatin; C-reactive protein; Interleukin-10; Tumor necrosis factor-α