The Effect of the Changes of Interleukin-13,Interleukin-18 and TNF-α Levels on Potential Implication in Patients with Asthma

Objective To discuss the potential implication of Interleukin-13,Interleukin-18 and TNF-α on the development of asthma.Methods 48 patients with asthma and 40 normal individuals were recruited into the study.The plasma levels of IL-13,IL-18 and TNF-α were assayed by the ELISA procedures.Results(1)The serum levels of IL-13,18 and TNFα were significantly increased in the patients with asthma at the acute(P0.01) stage compared with healthy controls.(2)The serum concentration of IL-18 and TNF-α changed significantly after treatment with glucocorticoid in patients with acute asthma.Conclusion The serum concentrations of IL-13,IL-18 and TNF-α were significantly higher in patients with acute asthma than the healthy control group.The alterations of the serum IL-13,IL-18 and TNF-α levels after treatment with glucocorticoid in patients with acute asthma showed significant implications.It suggested that cytokines of IL-13,18 and TNF-α have important roles in immune-pathogenesis of asthma.