2008•Central Plains Medical JournalRequires access

The efficiency of ulinastatin on seserum levels of proinflammatory cytokines in patients with severe acute pancreatitis

Hongchun Huang, Xiumin Wang, Peijie Huang, Fangjie Chen

Abstract

Objective To evaluate the therapeutic effects of ulinastatin on seserum levels of proinflammatory eytokines in patients with severe acute panereatitis(SAP). Methods 78 SAP patients were randomized into two groups:a treating group with ulinastatin and a control-treating group. All cases were observed for 7 days. The seserum levels of tumor necrosis factor-a (TNF-α),interleukine 6 (IL-6)were measured.Results ①The seserum levels of TNF-α,Il-6 and LPS were significantly higher in SAP patients (P<0.05).②After being treated for one week ,the seserum levels of TNF-αand IL-6 were significantly decreased in ulinastatin treatment group than those in standard treatment group (P<0.05). Conclusion Ulinastatin is beneficial to SAP patients, by redueing proinflammatory cytokines levels in seseum. Key words: Ulinastatin ; Proinflammatory eytokines; Severe acute panereatitis

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Key concepts: Ulinastatin, Proinflammatory cytokine, Medicine, Tumor necrosis factor alpha, Acute pancreatitis, Gastroenterology, Internal medicine, Context (archaeology)