2010•中国综合临床Requires access
Effect of trimetazidine in ischemic cardiomyopathy patients with impaired systolic function
Hongying Chen, Xuewei Chang
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Abstract
Objective To evaluate the effect of trimetazidine in ischemic cardiomyopathy patients with impaired systolic function. Methods There were 90 cases in total, and were divided into two groups randomly: 42patients took conventional therapy,and 48 patients took trimetazidine additionally. Plasma levels of brain natriuretic peptide (BNP), left ventricular ejection fraction(LVEF) and left ventricular end-diastolic dimension(LVEDD) were measured before and after trimetazidine therapy at 6 months, 12 months. Results Compared to conventional therapy group, LVEF, LVEDD and BNP were significantly improved in the trimetazidine group (P ＜ 0.01 ). Conclusions Trimetazidine additional to conventional therapy might improve heart function and reverse ventricles reconstitution in ischemic cardiomyopathy patients with impaired systolic function.
Key words:
Ischemic cardiomyopathy; Trimetazidine; Brain natriuretic peptide; Laft ventricular ejection fraction; Left ventricular end-diastolic dimension