Clinical observation of trimetazidine in the treatment of patients with congestive heart failure

Objective To explore the effects of trimetazidine on congestive heart failure in patients with ischemic cardiomyopathy and dilated cardiomyopathy.Methods Thirty cardiomyopathy patients (16 with ischemic cardiomyopathy and 14 with dilated cardiomyopathy) took trimetazidine 20mg after each of the three meals,besides routine therapy.Clinical effects were evaluated after 6 weeks of treatment.Left ventricular end diastolic diameter (LVEDD),left ventricular ejection fraction(LVEF) of echocardiography and cardiac function(NYHA) were measured before and after the treatment of trimetazidine.Results After 6 weeks of therapy,LVEDD decreased significaently [ (68.3 ±7.2)mm vs (53.2 ±5.4)mm,P 0.01 ],LVEF increased[ (0.36 ± 0.02)% vs (0.49 ±0.04)%,P 0.05],cardiac function(NYHA) improved 1 ～2 grade.There were no adverse reactions related to the drag.Conclusion Trimetazidine can improve the heart failure in patients with ischemic cardiomyopathy and dilated cardiomyopathy.