Clinical observation of infusion of intravenous diltiazem in treatment of refractory unstable angina

Objective To investigate the efficacy and safety of diltiazem to refractory unstable angina pectoris.Methods 42 unstable angina patients,who were failed to conventional anti-angina pectoris treatment,were treated with continuous infusion of intravenous diltiazem for 72 hours.Gradual titration of diltiazem was controlled.Angina attack frequency,ST segment depression and changes in blood rheologic indexes were observed before and after treatment.Results The attack of angina was effectively controlled after diltiazem treatment.The total effective rate was 90.1%.The average attack frequency,average attack duration and depression of ST segment were significantly decreased after diltizaem treatment(P ＜ 0.05).The blood pressure,heart rate ( P ＜ 0.05) and the systolic blood pressure × heart rate significantly decreased(P ＜ 0.01) after diltizaem treatment,without serious adverse reactions.Conclusion It was effective and safe to treat refractory unstable angina pectoris with diltizaem intravenous injection,but the dose titration should be strictly controlled. Key words: Refractory unstable angina; Diltiazem; Efficacy; Security