Diltiazem in Treatment of Refractory Unstable Angina Pectoris:Clinical Observation of 38 Cases

[Objective]To investigate the efficacy and safety of diltiazem to refractory unstable angina pectoris.[Methods]38 unstable angina patients,who were failed to conventional anti-angina pectoris and antithrombotic treatment,were treated with continuous infusion of intravenous diltiazem for 72 hours instead of nitrate and metoprolol.Gradual titration of diltiazem was controlled.Angina attack,ST segment depression and changes in blood rheologic indexes were observed before and after treatment.[Results]The attack of angina was effectively controlled after diltiazem treatment.The total effective rate was 92.1%.The average attack frequency,average attack duration and depression of ST segment were significantly decreased after diltizaem treatment(P0.01).The blood pressure,heart rate(P0.05)and the systolic blood pressure × heart rate significantly decreased(P0.01) at 24,48 and 72 hour after diltizaem treatment,without serious adverse reactions.[Conclusion]It was effective and safe to treat refractory unstable angina pectoris with diltizaem intravenous injection,but the dose titration should be strictly controlled.