Infection status of human papillomavirus and its genotype distribution among 24 450 women in Meizhou, Guangdong province

Objective To investigate the situation of human papillomavirus (HPV) infection and the distribution of HPV genotypes among women attending hospital in Meizhou, Guangdong province. Methods Flow-through hybridization and gene chip technique was used to detect HPV in cervical exfoliated cell specimens collected from 24 450 women for HPV screening in Department of Gynecology, Meizhou People′s Hospital, Meizhou Hospital Affiliated to Sun Yat-sen University, and then the situation of HPV infection and distribution of HPV genotypes were analyzed. Results Among 24 450 female exfoliated cell specimens, 3 922 were found to be positive for HPV infection, with the total infection rate of 16.04%. Among 3 922 samples, the top three high-risk subtypes of HPV were HPV-16 (30.37%), HPV-52 (17.77%) and HPV-58 (15.53%), the majority of low-risk HPV was HPV-CP8304 (5.61%). The positivity of various HPV types peaked among 30-50 years old. The differences of the HPV positive rates in different age groups was statistical significance (P<0.001). Conclusions The majority of women attending hospital detected with HPV-16 in Meizhou and the positivity of various HPV types peaked among women aged 30-50 years. Genotyping of HPV was meaningful for preventing and treating cervical cancer. Key words: Human papillomavirus; Flow-through hybridization; Genotyping