Validated Spectroscopic Method for Estimation of Tramadol Hydrochloride from Tablet Formulation

Tramadol hydrochloride is a centrally acting analgesic, used for treating moderate to severe pain. Various methods for analysis of the same are available but are time consuming and expensive. Here we have developed a new, precise and simple UV spectrophotometric method for estimation of tramadol hydrochloride from tablet formulation. The drug obeyed the Beer's law and showed good correlation. Absorption maxima of tramadol hydrochloride in methanol diluted with distilled water was found to be at 270.5nm. Beer's law was obeyed in concentration range 0 – 20 mcg/ml. The results of analysis were validated by recovery studies. The recovery was more than 99%. The method was found to be simple, accurate, precise, economical and robust.