2010•Asian Journal of Research in ChemistryRequires access

A Validated Reverse Phase HPLC Method for the Simultaneous Estimation of Atorvastatin Calcium and Ezetimibe in Pharmaceutical Dosage Forms

Nagaraju Pappula, Z Vishnu Vardhan, Jvln Seshagiri Rao

Abstract

A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Atorvastatin calcium and Ezetimibe in pharmaceutical dosage forms. The mobile phase consisted of Acetonitrile: buffer (0.1% v/v ortho phosphoric acid, PH – 6) in the ratio 60:40 delivered at a flow rate of 1ml/min and wavelength of detection at 232nm. The retention times of Atorvastatin calcium and Ezetimibe were 3.7 min and 6.1 min respectively. The developed method was validated according to ICH guidelines. The proposed method can be used for determination of these drugs in combined dosage forms.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Ezetimibe, Dosage form, Phosphoric acid, Chromatography, Atorvastatin, Chemistry, High-performance liquid chromatography, Phase (matter)