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2020•Research Journal of Pharmacy and TechnologyRequires access

Novel Stability indicating RP-UPLC Method for simultaneous Determination of Ivabradine and Metoprolol drug materials in bulk and their Pharmaceutical Dosage Forms

Suresh Gandi, A. Manikandan, S. Venkat Rao

Open publisher page 5 citations

Abstract

A simple, Accurate, precise method was developed for the simultaneous determination of the Ivabradine and Metoprolol in Pharmaceutical dosage form. Chromatogram was run through SB C8 100 x 3.0mm, 1.8μm. Mobile phase containing Buffer 0.01N Potassium dihydrogen ortho phosphate: Acetonitrile chosen in the ratio 50: 50v/v was pumped through column at a flow rate of 0.3 ml/min. Temperature and Wave length was optimized at 30°C and 260 nm independently. Percentage of recovery was obtained as 100.03% and 100.03% for Ivabradine and Metoprolol individually. LOD, LOQ values obtained from regression equations of Ivabradine and Metoprolol were 0.03, 0.08 and 0.12, 0.35 respectively.

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A simple, Accurate, precise method was developed for the simultaneous determination of the Ivabradine and Metoprolol in Pharmaceutical dosage form. Chromatogram was run through SB C8 100 x 3.0mm, 1.8μm. Mobile phase containing Buffer 0.01N Potassium dihydrogen ortho phosphate: Acetonitrile chosen in the ratio 50: 50v/v was pumped through column at a flow rate of 0.3 ml/min. Temperature and Wave length was optimized at 30°C and 260 nm independently. Percentage of recovery was obtained as 100.03% and 100.03% for Ivabradine and Metoprolol individually. LOD, LOQ values obtained from regression equations of Ivabradine and Metoprolol were 0.03, 0.08 and 0.12, 0.35 respectively.

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Available abstract

A simple, Accurate, precise method was developed for the simultaneous determination of the Ivabradine and Metoprolol in Pharmaceutical dosage form. Chromatogram was run through SB C8 100 x 3.0mm, 1.8μm. Mobile phase containing Buffer 0.01N Potassium dihydrogen ortho phosphate: Acetonitrile chosen in the ratio 50: 50v/v was pumped through column at a flow rate of 0.3 ml/min. Temperature and Wave length was optimized at 30°C and 260 nm independently. Percentage of recovery was obtained as 100.03% and 100.03% for Ivabradine and Metoprolol individually. LOD, LOQ values obtained from regression equations of Ivabradine and Metoprolol were 0.03, 0.08 and 0.12, 0.35 respectively.

Key concepts: Ivabradine, Metoprolol, Drug, Pharmaceutical formulation, Mathematics, Dosage form, Biomedical engineering, Pharmacology

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Novel Stability indicating RP-UPLC Method for simultaneous Determination of Ivabradine and Metoprolol drug materials in bulk and their Pharmaceutical Dosage Forms — Research Paper | ScholarLens