Effect of trimetazidine on the patients with stable angina pectoris and the influence of trimetazidine on C-reactive protein

Objective To observe the curative effect of trimetazidine hydrochloride tablets on the patients with stable angina pectoris and the influence of trimetazidine hydrochloride tablets on C-reactive protein (CRP).Methods Firty-eight patients with stable angina pectoris were randomly divided into two groups the test group (n =30) and the controll group (n =28).In the control group,the patients took aspirin,β-blockers,statins and nitrate drugs such as conventional treatment; in the test group,trimetazidine hydrochloride tablets were given in addition to conventional therapy. The treatment durations in both groups were 4 weeks.Evaluate the clinical effect and the mend matters of angina; at the same time,to detect the change of C-reactive protein level in serum of the patients with stable angina pectoris.Results After treatment,the total effectiveness in the test group was significantly higher than that in the control group (P ＜ 0.05).Two groups of patients with clinical efficacy difference was statistically significant (P ＜0.05 ).After treatment,the serum C-reactive protein level in the two groups was also statistically significant (P ＜ 0.05).Conclusions Trimetazidine hydrochloride tablets can obviously improve the clinical curative effect on the patients with stable angina pectoris by notable depressing the level of CRP. Key words: Trimetazidine;  Coronary heart disease;  Stable angina pectoris;  C-reactive protein