2001Chin J Naut Med & Hyperbar MedRequires access

The distribution characteristics and ultrastructural changes of residual cochlear spiral ganlion cells after blast exposure in guinea pigs

周义德, 沈小华, 吴皓, 李兆基, 翟所强, 杨伟炎

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Abstract

目的探讨爆震后豚鼠耳蜗残存螺旋神经节细胞分布特点及超微结构改变.方法复制爆震致聋豚鼠模型.取耳蜗做病理检查.观察耳蜗残存螺旋神经节细胞分布特点及其超微结构变化.结果爆震组21 d的耳蜗螺旋神经节细胞在耳蜗中轴切片的二下部位为(27.0±6.9)个;而正常对照组耳蜗中轴切片的二下部位为(51.0±4.7)个,两组间统计学差异有显著意义.豚鼠螺旋神经节细胞透射电镜观察爆震组震后3 d出现明显线粒体肿胀,线粒体嵴断裂;21 d后线粒体数量明显减少,且有畸形.而同期的正常对照组未发生上述现象.结论爆震后耳蜗螺旋神经节细胞数量减少,残留神经细胞线粒体超微结构有明显病变.

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目的探讨爆震后豚鼠耳蜗残存螺旋神经节细胞分布特点及超微结构改变.方法复制爆震致聋豚鼠模型.取耳蜗做病理检查.观察耳蜗残存螺旋神经节细胞分布特点及其超微结构变化.结果爆震组21 d的耳蜗螺旋神经节细胞在耳蜗中轴切片的二下部位为(27.0±6.9)个;而正常对照组耳蜗中轴切片的二下部位为(51.0±4.7)个,两组间统计学差异有显著意义.豚鼠螺旋神经节细胞透射电镜观察爆震组震后3 d出现明显线粒体肿胀,线粒体嵴断裂;21 d后线粒体数量明显减少,且有畸形.而同期的正常对照组未发生上述现象.结论爆震后耳蜗螺旋神经节细胞数量减少,残留神经细胞线粒体超微结构有明显病变.

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Available abstract

目的探讨爆震后豚鼠耳蜗残存螺旋神经节细胞分布特点及超微结构改变.方法复制爆震致聋豚鼠模型.取耳蜗做病理检查.观察耳蜗残存螺旋神经节细胞分布特点及其超微结构变化.结果爆震组21 d的耳蜗螺旋神经节细胞在耳蜗中轴切片的二下部位为(27.0±6.9)个;而正常对照组耳蜗中轴切片的二下部位为(51.0±4.7)个,两组间统计学差异有显著意义.豚鼠螺旋神经节细胞透射电镜观察爆震组震后3 d出现明显线粒体肿胀,线粒体嵴断裂;21 d后线粒体数量明显减少,且有畸形.而同期的正常对照组未发生上述现象.结论爆震后耳蜗螺旋神经节细胞数量减少,残留神经细胞线粒体超微结构有明显病变.

Key concepts: Ultrastructure, Guinea pig, Residual, Spiral (railway), Distribution (mathematics), Biology, Anatomy, Mathematics

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The distribution characteristics and ultrastructural changes of residual cochlear spiral ganlion cells after blast exposure in guinea pigs — Research Paper | ScholarLens