2008•白血病·淋巴瘤Requires access
The significance of protein C in acute leukemia patients with disseminated intravascular coagulation
Ruijuan Zhang, Xiue Liu, Linhua Yang, Bin Yu
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Abstract
Objective To investigate diagnostic and prognostic significance of protein C in acute leukemia with disseminated intravaseular coagnlation(DIC). Methods APTT, P-T, D-Dimer, Fbg, antithrombin (AT) and protein C(PC) were determinated in plasma of 44 DIC patients with acute leukemia and 30 normal controls. Results PC was markedly lower in disseminated intravaseular coagulation with acute leukemia group(67.03±36.98) than that of control group (99.53±45.20), and significantly correlation DIC score( r = -0.57,P＜0.01). PC of abnormality rate in DIC group was 86.36 %. APTT, PT, D-Dimer, Fbg were significantly increased and AT was decreased during the progress of DIC in relation to values observed in the control group. Conclusion DIC is related to the disorder of coagulation and fibfinolysis system. PC is a sensitive index to diagnose and prognose DIC in acute leukemia.
Key words:
Leukemia, promyelocytic, acute; Leukemia, lymphocytic, acute; Leukemia,myelocytic, acute; Disseminated intravascular coagulation; Proteins C; Diagnosis