The Significance and Laboratry Analysis in Acute Leukemia Patients with Disseminated Intravascular Coagulation

Objective: To investigate changes of disseminated intravascular coagulation (DIC) in acute leukemia(AL) and to discuss its implication. Methods: Screening tests of blood coagulation(activated partial thromboplastine time ( APTT), thrombin time(TT), prothrombin time(PT), fibrinogen(Fbg), D-Dimer, fibninogen degradation products and plasma protamine paracoagulation test were detected in 487 patients with AL. Results: There was significant difference between DIC groups and non-DIC groups withAL(PT P0.05, APTT P0.01). The patients with acute promyelocytic leukemia(APL) was abnormalsignificantly in lab detection, which is concided with clinical conditions, the lab index(except Fbg) was more abnormal in hybrid acute leukemia(HAL) and chronic myelogenous leukemia-accclarated phase(CML-AP) than other subtypes AL. D-Dimer abnormal rate was 96.06%, it indicated that D-Dimer was a special index in early diagnosis for DIC. Conclusion: According to abnormalities of DIC results, not only can reach a prompt diagnosis of DIG, but it also gave patients timely prevention and treatment, so to decrease the mortality of DIC.