The significance of molecular markers of blood coagulation and hemostasis in acute leukemia complicated with disseminated intravascular coagulation

Objective To investigate the value of molecular markers of blood coagulation and hemostasis measurement in diagnosis and prognosis estimate of acute leukemia complicated with disseminated intravascular coagulation(DIC).Methods A series of blood coagulation and hemostatic molecular markers,including GMP-140、AT-Ⅲ、 TAT、D-D、F1+2 PAP were measured in 77 patients with acute leukemia(37 cases with DIC and 40 cases without DIC) and 38 cases normal controls.Results The plasma levels of F1+2、D-D and TAT were significantly higher in early stage of DIC than in normal controls group(P0.01),levels of GMP-140 and PAP were significantly higher in early stage of DIC than in normal controls group(P0.05),and the activities of AT-Ⅲ was significantly lower than those in control group(P0.05).The plasma levels of F1+2、D-D、 TAT and GMP-140 were significantly higher in mid and late stage of DIC than in normal controls group(P0.01),and the activities of AT-Ⅲ was significantly lower than those in control group(P0.01).the D-D levels showed positive correlation with F1+2、GMP-140、TAT(r=0.871,P0.01;r=0.697,P0.05;r=0.763,P0.05).The plasma levels of GMP-140、D-D、PAP were significantly higher and the activities of AT-Ⅲ was significantly lower than those in control group(P0.05).The plasma levels of GMP-140、TAT、F1+2、D-D、PAP in patients acute leukemia with DIC were significantly higher than those in patients acute leukemia without DIC(P0.05).Conclusion The molecular markers of blood coagulation and hemostasis are sensitive indexes,which can early reflect coagulation,anti-coagulation and fibrinolysis.They had important practical value in the early diagnosis of DIC.monitoring the levels molecular markers of blood coagulation and hemostasis may have prognostic value in clinical outcome and is useful marker treatment of AL patients.