Study on the levels of plasma B-type natriuretic peptide and fibrinogen and their significance among different clinical phenotypes of coronary heart disease

Objective To explore the differences of levels of B-type natriuretic peptide(BNP)and fibrinogen(FIB)and clinical phenotypes of coronary heart disease(CHD).Methods 100 patients with CHD were enrolled in this study,including 45 patients with acute myocardial infarction(AMI),29 patients with unstable angina pectoris(UAP),and 26 patients with stable angina pectoris(SAP);20 subjects without CHD were taken as controls.Plasma levels of BNP as well as FIB were detected at 16 to 20 hours after the appearance of symptoms in AMI group or on admission in other groups.Results ①BNP was higher,in AMI group than in other three groups(P＜0.01),in UAP group than in SAP and control group(P＜0.01),in SAP group than in control group(P＜0.05),in patients who had complex lesions compared with those who had simple or no lesions(P＜0.01);②FIB was higher,in AMI group than in other three groups(P＜0.01),higher in UAP group than in control group(P＜0.05),higher in patients who had complex lesions than in those who had simple or no lesions(P＜0.01).Conclusion Plasma levels of BNP and FIB are closely associated with clinical phenotypes of CHD and differences exist between their levels. Key words: Coronary heart disease;  B-type natriuretic peptide;  Fibrinogen