Evaluation of correlation between liver pathological change and clinical indices in 76 chronic hepatitis B virus carriers

Objective To analyze correlation between hepatic:damage or fibrosis and albumin(AIB),globulin (GLB) and quantity of serum HBV DNA in chronic hepatitis B virus carriers for seeking some better clinical indices.To confirm the difference between clinical diagnosis and pathological diagnosis by means of liver biopsy.Metbods From March 2009 to December 2011,76 liver biopsies of chronic hepatitis B virus carriers were reviewed pathohistologically.albumin( ALB),globulin( CLB) and quantity of HBV DNA were collected sirmultaneously half a month before and after the biopsy. The correlations were assessed between hepatic pathohistology and clinical indices. The coincidence was evaluated between clinical and pathological diagnosis simultaneously.Results About 85.52 ％ ( 65/76 ) of the patients showed different degrees of inflammation(G) or fibrosis(S). For the degree of inflammation C0-1 was 60.53 ％ ( 46/76). and G2-4 was 39.47 ％ ( 30/76). For the degree of fibrosis.S0-1 was 73.68 ％(56/76), and S2-4 was 26.32 ％ ( 20/76). The ALB in patients with inflammation level of C0-1 was much higher than C2-4( t =7.954,P ＜ 0.01 ),and in patients with fibrosis level of S0-1 was higher than S2-4( t =6.669,P ＜ 0.01) ; and the level of GLB were the opposite ( t =2.649.P ＜ 0.01 ; t=2.508,P ＜ 0.05 ). The HBV DNA level was irrelevant with inflammatory staging and fibrotic scoring grading ( x2 =0.034,0.819.P ＞ 0.05). The degree of fibrosis in the age ≥ 40 group was more severe than the age ＜40 group ( x2 =6.220,P ＜ 0.05). Conclusions Serum samples for ALB and CLB are considered tO be the valuable reference for clinical diagnosis.However,liver biopsy is indispensable for confirming liver inflammatory staging and fibrotic scoring grading. Key words: Hepatitis B virus; Liver biopsy; Albumin; Globulin; HBV DNA