2010•Linchuang gandanbing zazhiRequires access

Pathological and clinical analysis of liver biopsies in patients with chronic hepatitis B

Jing Yu

Abstract

Objective To investigate the relationship among serum HBV DNA,ALT,ALB,PT levels and liver tissue injuries in patients with chronic hepatitis B. Methods Routine biochemical liver function tests and serum HBV DNA levels were assayed in 252 patients with chronic hepatitis B,and the liver biopsies were performed and the grading and staging of the liver were routinely obtained. Results There was not obvious correlation between the inflammatory grading and fibrotic staging;Serum ALT and PT in patients with G4 were significantly higher than in with G1;Serum HBV DNA levels was not correlated with histological activity index or firbosis. Conclusion Liver biopsy still plays an unique role in judging the pathogenetic condition of liver in patients with chronic hepatitis B.

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Key concepts: Medicine, Grading (engineering), Liver biopsy, Pathological, Chronic hepatitis, Gastroenterology, Internal medicine, Liver function