Relationship between level of serum HBV DNA,ALT,HA and pathological changes in liver tissues of patients with chronic hepatitis B

Objective:To study the relationships between level of serum HBV DNA、ALT、HA and hapatic pathological and immunohistochemical changes in the patients with chronic hepatitis B.Methods:Pathological and immunohistochemical,examinations,of liver tissue liver function tests,serum HBV and HBV DNA detection were performed in 127 patients with chronic hepatitis B.Results:The inflammatory staging were significantly correlated with Alanine transaminase,the inflammatory staging and fibrotic scoring grading were significantly correlated with Hyaluronic acid,level of serum HBV DNA between the groups S0 and S1~4,and between the groups G0~1 and G2~4 were not significantly different.And the hepatic HBcAg positive group and HBcAg negative group were significantly different.Conclusion:Serum HBV DNA correlated with HBcAg expression in liver tissue,patients with normal or low serum ALT level should be encouraged to accept liver biopsy.It can determine the degree of liver inflammation and fibrosis and timing of treatment.