Survey on the glycated hemoglobin Alc level in civil pilots

Objective To investigate the glycated hemoglobin Alc level (HbAlc) and its role in diagnosing impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM) in civil pilots.Methods One hundred and fifty-one civil pilots,who were in routine physical examination in Civil Aviation General Hospital,were chosen as pilot group and 96 common examined personnel were taken as control group.The pilot goup was further analyzed by different HbAlc and FPG level to get the correlation between them.The level of fasting plasma glucose (FPG),lipid profiles,liver and renal function markers and HbAlc were measured and analyzed.Results No difference of HbAlc was observed between pilot and control group.The HbAlc levcl was significantly higher in IFG and T2DM sub-group than that in normal glucose sub-group (P＜0.01).The multiple linear regression analysis indicated that FPG,γ-glutamyl transferase (γ-GT),alanine transaminase (ALT),and serum creatinine (SCr) were the significant and independent influencing factors against HbAlc.The receiver operating characteristic (ROC) curve showed that HbAlc at the level of 5.6％ and 6.2％ was the best cut-off value for diagnosing and screening IFG and T2DM.Conclusions HbAlc may be the key indicator in diagnosing and monitoring IFG and T2DM,as well as in evaluating cardiovascular disease incidence for civil pilot.Besides routinely monitoring FPG in physical examination,HbAlc should be the indicator in assessing glucose metabolism for the pilot with T2DM and taking hypoglycemic drugs. Key words: Hemoglobin A, glycosylated;  Blood glucose;  Diabetes mellitus, type 2;  Date collection